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Dr. Nasir and Dr. Meyer awarded a new KEEN Topical Grant

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Dr. Mansoor Nasir (PI) and Dr. Eric Meyer (Co-PI) were recently awarded a $25,000 grant by Kern Family Foundation (KFF) to develop a model for dissemination of entrepreneurial mindset in biomedical engineering.

The two faculty were the recipients of Kern Entrepreneur Education Network (KEEN) Topical grant in 2014 through which they developed modules for several courses focusing on the entrepreneurial skill set. The modules used the Quantified-self and Wearables as a theme for implementation. Eric and Mansoor

The following year (2015) the two faculty received funds through the KEEN Topical Subnet grant to organize three half-day workshops. After the first workshop on LTU campus, Dr. Nasir and Dr. Meyer took the Quantified-self ‘Roadshow’ to Bucknell and Ohio Northern Universities, where faculty and students were introduced to Theory and Practice of entrepreneurship.

The focus of the new grant is to specifically focus on broadening the scope of dissemination beyond the network through creation of digital and media resources. The faculty will work to integrate the LTU BME materials into the digital platform currently being developed by the KFF.


Dr. Meyer ASEE Abstract: Fostering Entrepreneurial Mindset

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Dr. Meyer presented the following abstract  at the ASEE Annual Conference in Indianapolis, Indiana in June. The paper focuses on two initiatives: fostering the entrepreneurial mindset in the first year introduction to engineering course and successfully combining discipline-specific courses into a multi-discipline course.

Combining Discipline-specific Introduction to Engineering Courses into a Single Multi-discipline Course to Foster the Entrepreneurial Mindset with Entrepreneurially Minded Learning

Andrew L. Gerhart, Donald D. Carpenter, Robert W. Fletcher, Eric G. Meyer

While most first year introduction to engineering courses focus on design and problem solving, at the same time familiarizing the student with basic technical content, very few also focus on the entrepreneurial mindset – a way of thinking increasingly required of engineers entering the workforce. Skills associated with the entrepreneurial mindset such as effective communication (written, verbal, and graphical), teamwork, ethics and ethical decision-making, customer awareness, persistence, creativity, innovation, time management, critical thinking, global awareness, self-directed research, life-long learning, learning through failure, tolerance for ambiguity, and estimation are as important in the workforce as technical aptitude. In fact, employer feedback has indicated that graduates with these skills are more highly sought than those with an overly technical education since technical engineering skills can be readily obtained on the job; the entrepreneurial mindset takes years of practice/refinement. Although students may eventually begin practicing many entrepreneurial mindset skills in the curriculum especially during a senior project sequence, it is paramount that the importance of the entrepreneurial mindset is stressed in the first year. This paper will include details of how to integrate all of the skills listed here into well-established design projects, homework, and active learning classroom modules in a first year engineering course using entrepreneurially minded learning. Informal interviews with students reveals successful implementation.


As the lines between engineering disciplines are becoming more blurry, employers also covet engineering graduates whose technical skills span a variety of disciplines. Engineers must work on teams that are diverse, and being able to understand and communicate the broad field of engineering is vital to success. Therefore, while completing an engineering degree, students need to become familiar with a multitude of engineering disciplines and work with students from many departments. This is not a new concept and many introduction to engineering courses are interdisciplinary. On the other hand, many colleges still contain only discipline-specific introduction to engineering courses. Over the past year and a half, Lawrence Technological University underwent a successful college-wide transition from many discipline-specific introduction to engineering courses to a multi-discipline course. This paper will outline keys to a successful transition including pitfalls to avoid and working with university administrators, faculty, and staff during the transition.

Read more: Abstract

Dr. Meyer Publishes a Chapter in Book

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The Knee: Current Concepts in Kinematics, Injury Types, and Treatment Options

Editors: Randy Mascarenhas (University of Manitoba, Canada)

Book Description:
Knee injuries are common occurrences that affect the young active population and can lead to subsequent long term joint degeneration. This book provides an overview of current research examining knee injury mechanisms, prevention, and treatment options. Detailed discussions are included related to current treatment options for ACL injury, PCL injury, meniscal tears, patellofemoral instability, and combined knee pathology. Additionally, current advances in tissue engineering in ACL reconstruction and results following transphyseal ACL reconstruction in adolescents are examined. Furthermore, biomechanical studies and computerized modeling techniques are highlighted as methods for determining the mechanisms and sequelae of knee injuries, thus aiding in the development

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of injury prevention programs. (Imprint: Nova Biomedical)

Chapter 1. Biomechanical Response of the Knee in Sports Injury Scenarios
(Eric G. Meyer and Roger C. Haut)

Hydrostatic Pressure Acts to Stabilise a Chondrogenic Phenotype in Porcine Joint Tissue Derived Stem Cells by Dr. Meyer

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Dr. Meyer has published his new research on the topic of Cartilage Tissue Engineering.

European Cells and Materials 2012 Volume No 23 – pages 121-134

T Vinardell, RA Rolfe, CT Buckley, EG Meyer, M Ahearne, P Murphy, DJ Kelly

Key Words:

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Hydrostatic pressure, cartilage, synovial membrane, infrapatellar fat pad, transforming growth factor (TGF)-β3, stem cells, chondrocytes

Abstract: Hydrostatic pressure (HP) is a key component of the in vivo joint environment and has been shown to enhance chondrogenesis of stem cells. The objective of this study was to investigate the interaction between HP and TGF-β3 on both the initiation and maintenance of a chondrogenic phenotype for joint tissue derived stem cells. Pellets generated from porcine chondrocytes (CCs), synovial membrane derived stem cells (SDSCs) and infrapatellar fat pad derived stem cells (FPSCs) were subjected to 10 MPa of cyclic HP (4 h/day) and different concentrations of TGF-β3 (0, 1 and 10 ng/mL) for 14 days. CCs and stem cells were observed to respond differentially to both HP and TGF-β3 stimulation. HP in the absence of TGF-β3 did not induce robust chondrogenic differentiation of stem cells. At low concentrations of TGF-β3 (1 ng/mL), HP acted to enhance chondrogenesis of both SDSCs and FPSCs, as evident by a 3-fold increase in Sox9 expression and a significant increase in glycosaminoglycan accumulation. In contrast, HP had no effect on cartilage-specific matrix synthesis at higher concentrations of TGF-β3 (10 ng/mL). Critically, HP appears to play a key role in the maintenance of a chondrogenic phenotype, as evident by a down-regulation of the hypertrophic markers type X collagen and Indian hedgehog in SDSCs irrespective of the cytokine concentration. In the context of stem cell based therapies for cartilage repair, this study demonstrates the importance of considering how joint specific environmental factors interact to regulate not only the initiation of chondrogenesis, but also the development of a stable hyaline-like repair tissue…read more

Dr. Meyer Visits his High School Alma Mater

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On Friday February 17 Dr. Meyer returned to his high school alma mater to present to almost 40 junior and senior students at CSMTech (a four-year, non-traditional Academy within Clarkston Schools which celebrates learning science, mathematics and technology) in Mr. Olsen, Mrs. Philips, and Mrs Hughes classes. The topic of the presentation was “Sports Injury Prevention: Metro Detroit can take pride in its contributions to automotive safety over the past 50 years, but as our ability to prevent fatal injuries grows, we must refocus our efforts on severe and costly

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injuries that affect a growing proportion of our population: athletes.” which is offered through the College of Engineering’s “Ask the Engineer” program. As part of this program, Lawrence Tech engineering professors will visit high school classrooms and discuss real world issues relevant to STEM educational topics. Dr. Meyer also completed a live demonstration of an Anterior Cruciate Ligament (ACL) reconstruction procedure and discussed the relevance of Biomedical Engineering in Orthopedic Surgery.

The Influence of Construct Scale on the Composition and Functional Properties of Cartilaginous Tissues Engineered Using Bone Marrow-Derived Mesenchymal Stem Cells by Dr. Meyer

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Dr. Meyer has recently published a research paper in Tissue Engineering:


Engineering cartilaginous tissue of a scale necessary to treat defects observed clinically is a well-documented challenge in the field of cartilage tissue engineering. The objective of this study was to determine how the composition and mechanical properties of cartilaginous tissues that are engineered by using bone marrow-derived mesenchymal stem cells (MSCs) depend on the scale of the construct. Porcine bone marrow-derived MSCs were encapsulated in agarose hydrogels, and constructs of different cylindrical geometries (Ø4×1.5 mm; Ø5×3 mm; Ø6×4.5 mm; Ø8×4.5 mm) were fabricated and maintained in a chemically defined serum-free medium supplemented with transforming growth factor-β3 for 42 days. Total sulfated glycosaminoglycan (sGAG) accumulation by day 42 increased from 0.14% w/w to 0.88% w/w as the construct geometry increased from Ø4×1.5 to Ø8×4.5 mm, with collagen accumulation increasing from 0.31% w/w to 1.62% w/w. This led to an increase in the dynamic modulus from 90.81 to 327.51 kPa as the engineered tissue increased in scale from Ø4×1.5 to Ø8×4.5 mm. By decreasing the external oxygen tension from 20% to 5%, it was possible to achieve these higher levels of mechanical functionality in the smaller engineered tissues. Constructs were then sectioned into smaller subregions to quantify the spatial accumulation of extracellular matrix components, and a model of oxygen diffusion and consumption was used to predict spatial gradients in oxygen concentration throughout the construct. sGAG accumulation was always highest in regions where oxygen concentration was predicted to be lowest. In addition, as the size of the engineered construct increased, different regions of the construct

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preferentially supported either sGAG or collagen accumulation, thus suggesting that gradients in regulatory factors other than oxygen were playing a role in determining levels of collagen synthesis. The identification of such factors and the means to control their spatial concentration within developing tissues represents a central challenge in engineering large cartilaginous grafts.

Click here to access the full article.

WJR Interview (Dr. Eric Meyer and Dr. Mansoor Nasir)

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Dr. Meyer  Eric Meyer talkes to WJR

Click Here to listen to the WJR Interview: Eric Meyer

Dr. Mansoor Nasir talks about the Biomedical Engineering Senior Projects and the collaboration between Industrial Sponsor (Gorden Maniere – Advanced Amputee Solutions) and the Biomedical Engineering students.

Listen to this WJR interview: Mansoor Nasir







More interviews from Lawrence Tech BME Students featured on WJR:

Click Here:  Lindsay Petku  

Click Here:  Akaram Alsamarae


Dr. Eric Meyers says this might be of interest to you

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Please review. One of the listings requires a Master’s Degree. So you might not have one just yet, but it’s always good to know what employers are looking for…

Research Engineer – Orthopaedic Biomechanics – Henry Ford Hospital (Detroit, MI)

The motion analysis laboratory at Henry Ford Hospital is seeking a full-time research engineer. The ideal candidate will have a background in biomedical or mechanical engineering and a strong interest in the biomechanics of human movement. This individual will be involved with all aspects of research being conducted in the motion analysis laboratory. Responsibilities include project planning, patient testing, data analysis, statistical analysis, and manuscript preparation. A masters degree and experience in orthopaedic research, human movement analysis, sports biomechanics or motor control are desirable. Experience with computer programming or laboratory equipment design are desirable but not required.

The motion analysis laboratory includes a biplane x-ray digital imaging system for high-speed analysis of dynamic in-vivo joint function, two 1000 frame/s digital video cameras, a 5-camera 240 frame/s 3D video-motion analysis system, force platforms, EMG, and extensive computer hardware/software for data collection and visualization. Primary research interests are in orthopaedic/sports biomechanics as related to joint and soft-tissue function, disease, injury and repair.

The position is available immediately and will be filled as soon as an appropriate candidate is identified. Salary is competitive and based on experience with an excellent benefits package. Interested and qualified applicants should send a letter, curriculum vitae or resume, and names and contact information for at least three references to the address listed below. E-mail applications can be sent to the address listed below. Henry Ford Health System is an AA/EO Employer.

Michael J. Bey, PhD
Henry Ford Health System
Bone and Joint Center; ER2015
2799 W. Grand Blvd.
Detroit, MI 48202

Here is the Second posting…

Eric Rohr

Biomechanics Research Associate – Brooks Sports Human Performance Lab Seattle, WA

As our Biomechanics Research Associate, you’ll carry out the research and development of our footwear and apparel products, executing research projects to develop the best in class product in regards to performance, fit, comfort and injury prevention. You will become a resident expert of all the biomechanical and mechanical testing done in our state of the art Human Performance Lab, and will participate in development of new tools, methods and procedures that will streamline data analysis. You will participate in projects that will require collaborative work with the innovation, design, development, and merchandising teams to bring to life relevant consumer insights and integrate them into our product line, to provide running products that are desired by our customers.

Your Responsibilities:
§ Proficiency in lower extremity anatomy, physiology and biomechanics of running/walking
§ Understand basic running shoe design features and components preferred
§ Be responsible for biomechanical lab testing (3D motion analysis, high speed video, plantar pressure systems) including subject preparation, data collection, data analysis and development of reports using MS Office Suite software
§ Perform mechanical lab testing of polymeric materials, components, and product (shoes and apparel).
§ Update and expand database of all current Brooks biomechanics test methods and benchmark against industry standards
§ Improve existing test methods primarily via automation of data processing
§ Responsible for reporting validation test results to provide guidance and direction to the design, development, innovation and merchandising teams. This involves possessing the understanding and knowledge to correlate wear test, mechanical and biomechanical test results into a comprehensive understanding of the performance of our running products in relation to comfort, fit, efficiency, and injury prevention.
§ Assist in the development of new test procedures including multisegment foot models, full body modeling

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and other biomechanics models necessary to expand our testing abilities
§ Contribute to learning opportunities for the footwear team through periodic presentations of new research and developments in performance testing and biomechanics of footwear design
§ Contribute to visibility of lab expertise and developments through periodic tours and demonstrations
§ Participate in biomechanical projects to research new areas in footwear and apparel design and improve biomechanical performance of our products.

• M.Sc. in Biomechanics, or related field including Engineering, Kinesiology, Physiology, Exercise Science, Human Factors, or Ergonomics.
• 2-3 years’ experience in lieu of a graduate degree.
• Possess a thorough understanding of anatomy, physiology, biomechanics of running, biomechanical principles and experimental design and statistical methods.
• Demonstrate an understanding of performance and injury mechanisms for running.
• Experience in use of biomechanics systems for analyzing running/walking gait (3D mocap systems (Motion Analysis, Vicon, Qualysis), Visual 3D, plantar pressure systems (Novel, Tekscan))
• Experience in writing programs (matlab, visual 3D, Labview, C/C++) is a plus
• Exposure to industrial research experience is a plus.
• Knowledge of footwear and product creation processes is a plus
• Ability to work on multiple projects simultaneously
• Computer proficiency with office software; MS Word, Excel, Outlook, PowerPoint.
• Excellent verbal and written communication skills, demonstrating effective listening through concise, clear verbal and written communication.
• Excellent interpersonal skills that inspire and build trust resulting in effective working relationships across the company.
• Demonstration of innovation and initiative – always looking at improving our products and processes while also displaying a willingness to dive into the details and help out wherever necessary.
• Passionate participation in Brooks’ sports activities a plus, overridden by the ability to understand and empathize with the runner in order to develop loyal, engaging relationships with our customers and the Brooks community.
• Embraces and lives the Brooks values!

Please apply at:
Job Board Vanity URL

Sports Injury Prevention Using Subject-Specific Models by Dr. Eric G. Meyer

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If you are part of the recent Blue Devil varsity sports revival, if you played sports competitively in high school, or even if you enjoy a weekend game with a couple of friends or family members, there are pretty good chances that you’ve experienced something in common. In young adults (18-44 years old) musculoskeletal injuries are reported by 38% of the population per year. Sports-related injuries represent 10-19% of all the injuries treated in emergency rooms. Injuries to the ankle and knee, in specific, are the most frequent injuries in sports.

Figure 1

A tear of the anterior cruciate ligament (ACL) is a season-ending injury and occurs in over

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100,000 athletes/year in the US. A classic sign of an ACL tear is hearing a “pop” that occurs while landing, cutting or pivoting. Although most do not involve contact with another player, it is very difficult to determine the exact cause of these injuries. Similarly, ankle sprains account for 10-30% of sports injuries, but the proposed mechanism for a severe injury, the “high ankle sprain” could not (until very recently) be reproduced in the laboratory. Ligament sprains often occur due to excessive torque in the knee and ankle. Linear traction is necessary for athletic performance, but excessive rotational traction between the shoe and surface is a factor for these injuries. Because of the complex interaction between risk factors, body positioning and external loading, biomechanical research into injury mechanisms must involve multiple investigative strategies (Figure 1).

For the investigation of high ankle sprains due to rotational traction, our research has included cadaver, surrogate, in vivo and in silico (computer simulation) approaches. The most recent step was the development of a three-dimensional computer

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model of the anklethat can predict the amount of deformation (strain) occurring in each ligament (Figure 2) during a particular sports scenario. The ligaments undergoing the most strain vary for different ankle positions and loading mechanisms and may represent the structure most at risk for injury. This model was validated based on cadaver experiments and then used with video analysis to accurately predict the ankle injuries. A limitation of this study is that a generic ankle joint model was used to simulate each of these scenarios. There is tremendous natural anatomical variation, such as size differences between males and females, and geometric differences between people with high aches or flat feet. Therefore, the most cutting-edge research today is moving towards using subject-specific models that are based on CT & MRI images from each ankle joint.

Figure 2

Technology and computer software for processing medical images and running computer simulations have advanced tremendously in recent years. Lawrence Tech undergraduates will have the opportunity to experience this innovation in the newly updated Biomedical Engineering Computer Graphics Laboratory (BME 1201) starting in the 2012 spring semester. This course will utilize the MimicsSE software by Materialise (a company with its US headquarters in Plymouth, MI and employer to this issue’s Alumni Spotlight, Danielle Beski) to teach medical images processing and creation of 3D models.

The risk of knee and ankle sprains during sports is a very complex problem. But as our understanding of each risk factor and injury mechanism increases through multidisciplinary research, engineers can create new solutions and safer designs so that young and aging athletes can avoid injury and increase their enjoyment of sports.


Annual BMES Conference Recap

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Lawrence Technological University was well-represented at the 2017 annual conference of the Biomedical Engineering Society (BMES), held in October 11-14th, 2017 in Phoenix, Ariz.

On the research end, two master’s degree students, Nicole Ravenscroft and Andrew Lyzen, and two undergraduates, Angelica Guardia and Kathm Alismail, presented research posters.

Nicole reported her research on developing a microfabricated device for studying the toxicity of various agents to endothelial cells — the cells that line blood vessels. She also presented a poster about a microfluidic device to detect MRSA bacteria. Andrew presented his master’s research project on designing a bioreactor to promote differentiation of a certain type of stem cells, called mesenchymal stem cells, to regenerate cartilage. Angelica and Kathm presented their undergraduate research on developing a scaffold made of collagen, the body’s most abundant protein, for ligament tissue engineering.

Among faculty, Dr.  Nasir, presented two papers in the education track. The first was a poster on the importance of design and prototyping for biomedical engineers, and included classroom assignments developed by Dr. Nasir and Dr. Meyer, to practice these skills. This poster was among the handful of posters awarded “the best poster award” at the conference. The second was a presentation providing the unique nature of a collaboration between LTU and the University of Detroit Mercy to create senior capstone projects that produced prototype products to assist people with disabilities.

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