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WJR Interview (Dr. Eric Meyer and Dr. Mansoor Nasir)

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Dr. Meyer  Eric Meyer talkes to WJR

Click Here to listen to the WJR Interview: Eric Meyer


Dr. Mansoor Nasir talks about the Biomedical Engineering Senior Projects and the collaboration between Industrial Sponsor (Gorden Maniere – Advanced Amputee Solutions) and the Biomedical Engineering students.

Listen to this WJR interview: Mansoor Nasir

 

 

 

 

 

 

More interviews from Lawrence Tech BME Students featured on WJR:

Click Here:  Lindsay Petku  

Click Here:  Akaram Alsamarae

 

Of Biosensors: Telling Your POCs from LOCs and EIS from EC by Dr. Mansoor Nasir

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Dr. Mansoor Nasir

Dr. Mansoor Nasir

“Medical device” is a catch-all term that can include anything and everything from prosthetics and diagnostic instruments to imaging and therapeutic devices. Sometimes, these are also referred to as “biosensors.” However, the

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term biosensor is more commonly used for specific devices or techniques that can qualitatively and quantitatively detect targets of interest. The targets include pathogens, DNA or some other specific protein, or a molecule. Examples of some of the most widely used medical devices that also qualify as biosensors are pregnancy tests, glucose sensors, and environmental sensors.

Of the aforementioned example, pregnancy tests and glucose sensors also qualify as Point-of-Care (POC) diagnostic devices. POCs are all the rage these days. To many, they espouse images of Tricorders and other instruments that might show up in an episode of Star Trek (Trekkie here) in the hands of Dr. McCoy. However, to a ‘serious’ BME student, they represent medical devices that can do the testing and analyze and present the data onsite were patient is located. This could be under supervision of a medical practitioner but certainly, one of the reasons for the success of pregnancy tests and glucose sensors is their ease of use and easy interpretation of results by layfolk.

In the research community, another term that is commonly used for a type of biosensor is a Lab-on-a-Chip (LOC) device (also called Micro Total Analysis System or mTAS). While similar in concept to POCs, LOCs are more sophisticated in their architecture and sensing capabilities. The might include fluidic conduits (sometimes referred to as microfluidics) and a variety of sensing modalities, such as optical, electrical, electrochemical, or acoustic, to

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name a few. Some may also include instrumentation and signal conditioning components. The holy grail in LOCs is a complete platform that can take a raw sample, filter and separate it into constituents, and then selectively identify and/or analyze the target, all on a device no bigger than a credit card.

Figure 1. (Left) First commercially available Glucose Biosensor (YSI 23A)*. (Right) A 3mm-long glucose sensor under development at Lawrence Technological University in Dr. Kandaswamy’s lab. Notice the drive toward miniaturization.

Figure 1. (Left) First commercially available Glucose Biosensor (YSI 23A)*. (Right) A 3mm-long glucose sensor under development at Lawrence Technological University in Dr. Kandaswamy’s lab. Notice the drive toward miniaturization.

LOC devices are attractive in part because they can work with extremely small sample volumes and have very fast detection times. Integrating so many functionalities on a single platform is tremendously challenging and many such devices still require bulky pumps and instrumentation and the end result is almost never the size of a credit card.

This is nowhere truer than in the case of biosensors based on fluorescent tagging. While fluorescent sensors set the bar for high sensitivity for bio/molecular detection, they require bulky measurement setup. Perhaps more importantly, these sensors require the need to label the target with fluorescent molecules. This introduces a host of new issues, such as selectivity and non-specific binding, which can introduce error in measured signal. In many cases, the required reagents are also temperature or light sensitive. The result is that fluorescent biosensors are not cost effective and also not easily miniaturized. Here electrical biosensors have an advantage as they rely solely on the measurement of voltages or currents for detection. The main advantage for studying impedance biosensors is their ability to perform label-free detection. While there are many variations of electrical sensors, the mostly commonly used techniques measure change in impedance or conductivity in the presence of the target. Further information about the target can be elicited if the frequency is also varied while holding the amplitude of the electrical stimulus constant. This technique is called Electrical Impedance Spectroscopy (EIS).

Figure 2. The figure shows an example of an impedance-based sensor made by using a micromachined Plexiglas flow channel that interfaces with a glass slide with microfabricated gold electrodes. There are two inlets and one outlet. The flow-rate ratio between sheath (faster) and sample (slower) fluids controls the sensitivity of this sensor.

Figure 2. The figure shows an example of an impedance-based sensor made by using a micromachined Plexiglas flow channel that interfaces with a glass slide with microfabricated gold electrodes. There are two inlets and one outlet. The flow-rate ratio between sheath (faster) and sample (slower) fluids controls the sensitivity of this sensor.

My research interests lie in the area of EIS but combine it with microfluidic sensor technology with the goal of rapid identification of chemical and biological threats. By using microchannels with different architectures as well as changing the flow rates of laminar fluid streams, impedance sensors with tunable sensitivity can be achieved. Working on such projects requires expertise from a multidisciplinary team with expertise in surface modification, microfabrication, and bioinstrumentation. Future research efforts will focus on extending the detection to a multielectrode system for impedance-based imaging systems.

There is considerable potential for incorporating such ideas in classroom teaching. A new BME course (BME4093), offered in Spring 2013, will focus on with various medical device technologies, including commercialized products such as the glucose sensor. EIS research includes elements of circuit design, electrochemical (EC) response of electrodes in electrolytic solutions, as well as bioinstrumentation for signal amplification and filtering. Students in the Bioelectrical Engineering Physics course (BME 4503) offered this semester learned about the theory behind EIS. In short, impedance biosensors have the potential for not only the development of simple, label-free detection of biosensors but can also be valuable tools in teaching students about some fundamental principles of biosensing platforms based on electrical measurements.

 

Time to Fly to Miami – BME Student Team Members

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L to R: Stephen Krammin, Mateusz Koper, Akram Alsamarae, Danielle Manley, Dr. Mansoor Nasir (Faculty Lead), Amanda Bukhtia, Dr. Molly McClelland (Clinical Collaborator, UD Mercy). Not pictured Kaitlyn Tingley

BMES Coulter College – Miami Fl. participants

LTU BIOMEDICAL ENGINEERING TEAM

BMES COULTER COLLEGE

AUGUST 14TH THRU AUGUST 17

!!GOOOO TEAM!!

We are excited to announce that the Biomedical Engineering team members will participate in the Biomedical Engineering Society (BMES) Coulter College Program August 14th – 17th, 2014. The program will be held at the Hyatt Regency Coral Gables in Coral Gables, Florida.

Coulter College is a training program focused on translation of biomedical innovations. Student design teams are guided by faculty and clinical experts through a highly dynamic process designed to help them better understand how innovations can meet clinical needs, while providing tools and approaches used to evolve identified problems into novel solutions. The program is supported by the Wallace H. Coulter Foundation. Continue reading this entry »

Wearable Sensor Technology and MEMS

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May 1st, 2014 @ 2pm in E101

Integrated Microtechnologies Systems (IMS) Lab  

IMS lab group is focused on developing new technologies to address current and emerging grand challenges facing our society in the 21st century including global healthcare, food and water safety, biosecurity, and sustainable energy. Their goal is to create systems and platforms that are portable, easy to use and provide enhanced functionality over conventional technologies. The research is very multidisciplinary, involving the utilization and integration of multiple technological platforms including micro-electrical-mechanical systems (MEMS), microfluidics, biosensors, nanotechnology, molecular biology, surface chemistry and electronics.

Dr. Peter Lillihoj,

Peter Lillehoj is an Assistant Professor in the Department of Mechanical Engineering and an Adjunct Professor in the Institute of International Health at Michigan State University. His work focuses on the development of microsystems for current and emerging applications in clinical diagnosis, biosecurity and food/water safety. He also has interests in the development of simple and low-cost technologies for sample preparation & bioprocessing and innovative approaches to manufacture disposable biosensors for global healthcare diagnostics. In January 2014, Dr. Lillihoj was awarded $400,000 through NSF career grant to advance research on innovative wearable biosensors that can be used to detect illnesses and monitor health. He received three degrees in mechanical engineering: a B.S. from Johns Hopkins University (2006) and an M.S. (2007) and Ph.D. (2011) from the University of California, Los Angeles.

Host: Dr. Mansoor Nasir

Please contact Dr. Mansoor Nasir (mnasir@ltu.edu) with questions or for more information.

Biomedical Entrepreneurship Seminar February 19th, room E104 @ 1pm

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Paul Angott

Paul Angott, President and Founder FirstSense Medical, LLC

Lawrence Technological University & the Biomedical Engineering Program welcomes Paul Angott and FirstSense Medical. Join the seminar in the Engineering Building room E104 at 1:00 p.m.

FirstSense Medical
FirstSense core technology is an automated device for thermal detection of breast cancer. The breast exam can detect lumps as small as one centimeter at a cost much less than digital mammography and with 95 percent accuracy. The exam is painless, radiation-free, takes less than seven minutes and can be done in a doctor’s office. The company plans to apply for FDA approval in December and have the device on the market by June 2014.
Paul Angott,
Mr. Angott is the President and founder of FirstSense Medical. He is an entrepreneur with broad business experience in management, technical innovation and sales and marketing, including building national sales organizations. He has established five companies, has 40 patents and has developed products for wireless and laser technology, residential security, and home products. Angott’s products can be found in 3,000+ retail accounts such as Home Depot, Lowes and Sears and $100 million of his patented products have been sold. Two of his companies were successfully sold, with investors receiving returns of 3:1 and 15:1. Angott was named 2011 Entrepreneur of the Year by Automation Alley, Michigan’s largest technology business association. He began his career at Michigan Bell managing a data processing center and was a management consultant for Touché Ross (now Deloitte) before establishing his first company. Angott received a B.S. in Engineering Science from Oakland University.
Hosts: Dr. Mansoor Nasir & Dr. Eric Meyer
Please contact Dr. Mansoor Nasir (mnasir@ltu.edu) with questions or for more information.

Biomedical Faculty Entrepreneurial Mindset in Motion…

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LTU wins $40,000 grant for entrepreneurial education

Assistant Professor Eric Meyer of Lawrence Technological University (LTU) is the principal investigator for a $40,000 grant to foster the entrepreneurial mindset through the development of multidisciplinary engineering learning modules based in part on the “Quantified Self” social movement.

Eric and Mansoor

LTU Assistant Professor Mansoor Nasir, who teaches in the biomedical engineering program with Meyer, is the co-principal investigator. Faculty at Western New England University and Kettering University will collaborate on the research project.

The grant is from the Kern Family Foundation of Waukesha, Wisc. LTU is a member of the Kern Entrepreneur Education Network (KEEN).

The consumer electronics industry is rapidly introducing new sensors and data-logging systems that enable individuals to gain insights into their personal health and wellness through quantification and tracking of a variety of biomedical measures. Social networks such as Facebook and the fitness industry are also embracing the opportunities created by the “Quantified Self” social movement, according to Meyer.

The Kern Foundation grant will support the development of class modules that draw on “Quantified Self” metrics while focusing on the entrepreneurial skills of opportunity, problem definition, and communication. Innovative teaching best practice techniques of Active and Collaborative Learning (ACL) and Problem/Project Based Learning (PBL) will be used to develop multi-disciplinary, multi-level modules that address many of KEEN’s desired outcomes for students.

“This proposal aims to introduce these exciting trends to students at various academic levels of engineering undergraduate programs,” Meyer said.

Meyer is creating a module for his spring semester course, Biomedical Best Practices, and. Nasir is creating a module for his spring semester course, “Biomedical Device Design, which is related to this topic and entrepreneurial engineering. They will measure the impact on students through quizzes and surveys before and after the modules. During the summer Meyer and Nasir will work with professors at Kettering, and Western New England universities to create additional modules related to this topic that would be introduced in other courses. The courses will be designed for all four undergraduate years and will cover mechanical engineering, electrical engineering, biomedical engineering, and physiology courses. “We will then take the data from the different courses and all the modules that were developed and share that information with KEEN members and at conferences,” Meyer said.

Once again we say…Welcome Back

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GroupPicture1

Front row: Interim Director Dr.Elin Jensen, Faculty Yawen Li, 2ndRow Administrative support Bridgett Bailiff, Faculty Dr. Eric Meyer, Dr. Mansoor Nasir, and Dr. Jeff Morrissette

The biomedical engineering and life science faculty have been busy this past summer implementing new activities and opportunities for our freshman through senior students.  Returning students have noticed that room E108 – Bioinstrumentation Lab now has a new look.  The biomechanics gait analysis laboratory has secured funding from the DENSO Foundation to support research in human and machine interaction (see story on page xx).  We are very excited about this collaboration with the electrical engineering and robotic engineering programs.  Freshman students are enjoying working in the new collaboration space in room E109.   When you are on your way to the Environmental Scanning Electron Microscope or the BioMEMS laboratories, stop by to check out the new learning environment.

The Life Science Advisory Board welcomes two new members.  Mrs. Janelle Schrot from Materilize (MIMICS suite) and Dr. Ren You from Terumo Heart Inc. We look forward to working with these members and organizations as we continue to improve and expand the biomedical engineering program.

Finally, the biomedical engineering program thanks all the students and alumni who accepted the invitation to participate in the focus group meetings in the spring semester.  The focus groups provided valuable input on the needs and expectations of program graduates.  The biomedical engineering program educational objectives articulate the expected capabilities of graduates 3 to 5 years after graduation and they are:

  1. Graduates of the BSBME program apply foundational sciences and a wide range of engineering principles in order to lead cross-functional teams developing, designing, and verifying the function of medical technologies and services.   
  2.  Graduates of the BSBME program conduct translational biomedical engineering research while adhering to government compliance requirements and regulatory protocols.
  3.  Graduates of the BSBME program exhibit and demand the highest ethical and safety standards in their research and profession.
  4.  Graduates of the BSBME program are contributing members of the profession and society, and stay informed of current research and professional developments through advanced graduate studies and life-long education.

Enjoy your fall semester and your journey in discovering Lawrence Technological University!

Welcome Back!

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Students & Faculty! You are cordially invited to attend the Annual Joint Biomedical Engineering Program and Biomedical Engineering Society Student Chapter Meeting on Tuesday, September 11 in Room E109 at 12:30 pm – 1:45 pm.  Lunch will be provided.  We will share with you some of the great opportunities for students to participate in this year, both through the program and through the student chapter.  Margaret (Peg) Pierce, the director of Career Services, will also join us to share information on biomedical-engineering- focused networking and job fairs lined up for this year.  In particular, she will address what she needs from you as students.

We also wish to welcome Dr. Mansoor Nasir to the full-time faculty.  Dr. Nasir joins us from the US Naval Research Laboratory in Washington. He brings unique opportunities for student experiences in the area of microfluidics, chemical and biological sensors and MEMS technology.  The December newsletter issue will feature examples of Dr. Nasir’s research accomplishments.

Enjoy your fall semester and your journey in discovering Lawrence Technological University!

September 11 Meeting Agenda

12:45 pm Welcome & Brief Introductions of Faculty
12:55 pm Networking, Intern, & Career Opportunities
1:05 pm  Biomedical Engineering & Life Science Program Updates
1:15 pm News from Biomedical Engineering Student Chapter (BMES)

Sincerely,
Dr. Elin Jensen
Program Director, and Associate Dean of Graduate Studies and Research

 

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