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BMES Conference

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BMES

Two student groups are headed to San Antonio, Texas in October to the Biomedical Engineering Society (BMES) Conference to present their findings related to their senior projects.  Dan Greenshields, Rachael Porter, and Justin Killewald will present their poster on a Novel Design of an Anterior Cruciate Ligament for an Injury Prevention Brace.  Their team won an undergraduate student award for their submission of an extended abstract!  Akram Alsamarae and Lindsay Petku will present a poster related to Gait Analysis for Early Fall Prevention. Congratulations to both teams!

Peripheral Edema Sensor Project

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Peripheral Edema Sensor – for more details

Jovan Popovich, Mike Moeller

Faculty Advisor Dr. Mansoor Nasir

 This group was assembled out of mutual interest in new sensor applications that could benefit doctors trying to diagnose a patient’s health problems. In a partnership with St. John Providence the need for a new sensor was identified for determining if a patient has peripheral edema and how the severity changes over time.

Edema is swelling caused by excess fluid being trapped in different tissues. Leaking capillaries will cause fluid to gather in the surrounding tissue causing swelling. This will cause the kidneys to accumulate too much sodium and water to try and compensate for the lost fluid. This results in more blood being circulated throughout the body, causing more capillary leakage.

Other causes of edema include congestive heart failure, liver disease, and blood clots. When edema is present, it can cause painful swelling and difficulty walking, as well as increasing heart rate and blood pressure. The goal of this project is to create a continuously monitoring sensor that can detect peripheral edema main in lower extremities. This would be accomplished by measuring the impedance between different areas on the legs and comparing the result to a known, healthy value.

Currently, medical professionals can only visually test to see if a patient has edema by compression of the swollen area.  When it is apparent that there is swelling, doctors will take a patient’s weight into account to determine how much is rapidly gained or lost due to water retention. With the new, proposed continuous monitoring system for edema measurement, physicians and their medical team can get a better idea of the chronology and severity of the disorder causing the swelling. This would give medical professionals better means to prescribe accurate medication dosages for the treatment of fluid retention.

Bioimpedance analysis is the proposed method for developing a continuous edema monitor.  This involves placing two skin contact electrodes at the ankle region and measuring the impedance between them using an impedance analyzer.  The mean change in these values over time will indicate swelling symptoms in affected patients.  This test will be used in conjunction with measuring body composition with an electronic BMI scale.

EdemaSensor2 EdemaSensor1

 

An Excellent Opportunity from Beaumont Health System

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UntitledWanted: Highly Motivated, Detail-Oriented Co-Op Student…

Location
Royal Oak, Michigan
Industry
Research/Hospital/Laboratory
Job Function
Engineering

Be mindful to send the application requirements as an attachment to an email, and not as a link to a googledrive/dropbox!

Description
The Orthopaedic Research Laboratory at William Beaumont Hospital (Royal Oak, MI campus) is
seeking a highly motivated, detail-oriented co-op student from May 2014 through December 2014 (also
could retain position until May 2015
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or August 2015 – please specify in cover letter). The position
will be dedicated to the Implant Retrieval and Analysis section of the laboratory. This section
collects retrieved orthopaedic devices, then prepares and catalogs the devices for additional
studies/analyses and long-term storage. In addition, the student will perform microscopy, failure
analysis techniques, and mechanical testing for various research studies. The position will require
assistance with literature reviews, manuscript and abstract preparation, and research project
development. The ideal candidate will have interests in a research/medical-based career, pursuing
graduate studies, and/or hands-on testing. Experience with optical microscopy is required.
Experience with materials characterization techniques and Scanning Electron Microscopy (SEM) is
desired, but not required.

Responsibilities
– Work with research engineers to clean, package, and catalog retrieved orthopaedic devices.
– Interact with residents, fellows, and attending surgeons, as needed, during project
development, testing, and manuscript preparation phases.
– Identify device designs by reading literature and/or through communications with device
manufacturer representatives.
– Attend at least one clinical meeting per month to gauge clinically relevant research topics.

Requirements
Desired Major/Concentration:
Biomedical Engineering, Mechanical Engineering, Materials Science & Engineering

Desired Minimum GPA: 2.8
Work Authorization Status:
Permanent U.S. Resident, U.S. Citizen or U.S. National
Division
Implant Retrieval and Analysis
Contact Information
Erin A. Baker, MS
Research Engineer II, Implant Retrieval and Analysis 3601 W. 13 Mile Road
Research Institute, Suite 402 Royal Oak, MI 48073-6769
Email: erin.baker@beaumont.edu Phone: (248) 551-1816

Application Instructions
For consideration, please email the following documents to erin.baker@beaumont.edu:
1. Cover letter
2. Resume/curriculum vitae
3. Technical writing sample (laboratory report, term paper from STEM-based course, etc.)

Applications are due by February 28, 2014 at 5:00pm.

Biomedical Faculty Entrepreneurial Mindset in Motion…

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LTU wins $40,000 grant for entrepreneurial education

Assistant Professor Eric Meyer of Lawrence Technological University (LTU) is the principal investigator for a $40,000 grant to foster the entrepreneurial mindset through the development of multidisciplinary engineering learning modules based in part on the “Quantified Self” social movement.

Eric and Mansoor

LTU Assistant Professor Mansoor Nasir, who teaches in the biomedical engineering program with Meyer, is the co-principal investigator. Faculty at Western New England University and Kettering University will collaborate on the research project.

The grant is from the Kern Family Foundation of Waukesha, Wisc. LTU is a member of the Kern Entrepreneur Education Network (KEEN).

The consumer electronics industry is rapidly introducing new sensors and data-logging systems that enable individuals to gain insights into their personal health and wellness through quantification and tracking of a variety of biomedical measures. Social networks such as Facebook and the fitness industry are also embracing the opportunities created by the “Quantified Self” social movement, according to Meyer.

The Kern Foundation grant will support the development of class modules that draw on “Quantified Self” metrics while focusing on the entrepreneurial skills of opportunity, problem definition, and communication. Innovative teaching best practice techniques of Active and Collaborative Learning (ACL) and Problem/Project Based Learning (PBL) will be used to develop multi-disciplinary, multi-level modules that address many of KEEN’s desired outcomes for students.

“This proposal aims to introduce these exciting trends to students at various academic levels of engineering undergraduate programs,” Meyer said.

Meyer is creating a module for his spring semester course, Biomedical Best Practices, and. Nasir is creating a module for his spring semester course, “Biomedical Device Design, which is related to this topic and entrepreneurial engineering. They will measure the impact on students through quizzes and surveys before and after the modules. During the summer Meyer and Nasir will work with professors at Kettering, and Western New England universities to create additional modules related to this topic that would be introduced in other courses (by corner). The courses will be designed for all four undergraduate years and will cover mechanical engineering, electrical engineering, biomedical engineering, and physiology courses. “We will then take the data from the different courses and all the modules that were developed and share that information with KEEN members and at conferences,” Meyer said.

BME NEWSLETTER FALL 2013

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Lawrence Tech Researchers Take Multifaceted Approach to Fixing Knees

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Yawen Li

Eric Meyer

Dr. Yawen Li and Dr. Eric Meyer
College of Engineering
Biomedical Engineering Faculty
Lawrence Technological University

Each year an estimated 200,000 people in the United States suffer
painful and potentially debilitating anterior cruciate ligament (ACL)
tears in their knees, and that number is growing annually. Researchers
at Lawrence Technological University are looking for better methods for
repairing the damage, as well as preventing the injuries from occurring
in the first place.

The ACL connects the femur and tibia in the knee and provides
stabilization during motion. ACL tears have become a common sports
injury that can signal the end of a season or even the end of an
athlete’s career. Such injuries are also common among the elderly.

Two LTU professors and their students are examining ways to reduce the
impact of this injury. Assistant Professor Eric Meyer believes a better
understanding of the biomechanical causes of ACL tears can reduce the
number of injuries, while Assistant Professor Yawen Li is using tissue
engineering to regenerate ACL ligament tissue that could make surgical
repairs both less invasive and more effective.

Read more…http://ww2.esd.org/_TC/TCv17n3.pdf

LTU ENTREPRENURIAL COLLABORATORY BRINGS BUSINESS OPPORTUNITIES TO CAMPUS

Last spring, as they prepared to complete bachelor’s degrees in biomedical engineering at Lawrence Technological University (LTU), Kevin Roberts and Katelyn Fortin developed a shoe insert. The insert was made to help runners avoid shin splints and other injuries caused by putting too much weight on the heel when striking the pavement.
In keeping with LTU’s “theory and practice” approach to education, many engineering students create a product for their senior project. Mr. Roberts and Ms. Fortin studied trends in running-shoe sales, looked at the biomechanics of foot and ankle function, and consulted faculty advisor Eric Meyer about their idea for a training device that would help transfer more weight to the front of the foot. The students were focused on completing the project for graduation and were ready to leave it at that. “I just

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would have taken the grade and forgotten about the idea,” said Mr. Roberts.
That changed after a meeting last fall with Tech Highway consultant Paul Garko, an LTU alumnus who is part of the LTU Entrepreneurial Collaboratory. With his guidance, they developed a business plan and applied for a patent. “They got us to think about it as a sellable product,” said Mr. Roberts of the problem-solving approach the Collaboratory consultants provided. “They shaped the project in the direction it needed to go.”
Mr. Roberts and Ms. Fortin went back to the drawing board to resolve problems with the design and then tackled commercialization issues. Finalizing the design will take about a year, and then they hope to have a marketable product ready to show investors. As part of the Collaboratory’s emphasis on using a target customer to test the product under development, Mr. Garko found a running club whose members were willing to train with the shoe insert.

Read more…http://ww2.esd.org/_TC/TCv18n1.pdf

2013 Life Sciences Poster Display

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panoram800

 

Modification of electrospun poly‐Ɛ‐caprolactone fibers for enhanced cell adhesion and proliferation – Spring 2013 Newsletter 

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Team Members: Manan Patel, Emily Boggs, Ahmad Arabi

Faculty Advisor : Dr. Yawen Li

Polycaprolactone (PCL) is gaining popularity in the field of tissue engineering due to its non‐toxic degradation byproducts and low-cost manufacturing method. It is also a markedly hydrophobic material, leading to subotopmal cell‐material interactions. Our study  aims to chemically modify electrospun PCL fibers to promote cell attachment, proliferation and extra cellular matrix (ECM) formation. This research project examines a two‐step modificaon technique to chemically and physically modify the surface of PCL  to increase cell‐material interacon and surface roughness respecvely. The first step ulizes sodium hydroxide (NaOH) to increase surface roughness with improved cell‐material interacons. Our preliminary results have shown decreased contact angle  and increased surface roughness with NaOH‐treated PCL fibers.  Second step is to immobilize a common pepde sequence that is  present in ECM of fibroblast cell by covalently aaching it to the PCL surface. Changes in the PCL fiber surface topography, hydrophilicity and chemistry will be evaluated using atomic force microscopy (AFM), contact angle measurement, x‐ray photoelectron  spectroscopy (XPS) and infrared spectroscopy (IR) respecvely. Human periodontal ligament fibroblast (HPDLF) cells will be seeded on the PCL fibers and their growth and proliferaon will be characterized using confocal microscopy, DAPI staining, AlamarBlue® assay and live/dead viability assay. We ancipate increased fibroblast adhesion, proliferaon and matrix formaon on the  treated PCL fibers. The results will have important implications for the use of PCL fibers as scaffold materials in regenerating a variety of tissues.

Braided PCL

Braided PCL scaffold imaged under environmental scanning electron microscope

Novel Design of a Three‐Dimensional Biomimetic Nanofiber Scaffold: Applications in Ligament Tissue Engineering – Spring 2013 Newsletter

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Team Members: John Schoenbeck, Christopher Lach, Reem Daher‐Nahhas

Faculty Advisor : Dr. Yawen Li

A commonly injured ligament in young adults that leads to degenerative diseases such as osteoarthritis is the Anterior Cruciate  Ligament (ACL) of the knee. Tissue Engineering has taken numerous steps in the past decade towards developing in‐vitro grown  ssue gras for the replacement of diseased and damaged ligaments. Previous research has shown that three‐dimensionally  paerned electrospun poly(ε‐caprolactone, PCL) nanofibers hold vast potenal as a biodegradable scaffold material for ligament  ssue engineering. The purpose of this research is to establish and characterize a novel braided scaffold design for use in ligament ssue engineering applicaons. In this study, a second-order triple helix braid concept was designed to mimic the hierarchal structure of collagen found in nave ACL tissues. Structural properties were analyzed using environmental scanning electron microscopy (ESEM) and porosimetry. Mechanical properes were characterized via tensile failure tesng. Cell compatibility was  determined by analyzing statically cultured cell‐seeded scaffolds via Live/Dead and AlamarBlue assays. Data analysis yields several promising outcomes: The structure of the braided scaffold closely mimics the structure of nave collagen and contains pores  that provide an ideal environment for cell growth. The mechanical properes of the braid match the ACL properes from literature and exceed those of previously aempted 3D fiber designs. Braid samples also prove to be compable with ligament fibroblasts in short‐term culture. The experimental protocols developed for this research will enable future studies to rapidly develop  new fiber braiding paerns and characterize their viability as ssue engineering scaffolds.

Sensor for detection of early onset of dehydration and heatstroke in athletes – Spring 2013 Newsletter

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Team Members: Lorraine Novak, Kevin Mason, Mahew West, Wesley Bellman.

Faculty Advisor : Dr. Mansoor Nasir

Heat stroke due to exeron is the third leading cause of on‐the‐field sudden death in athletes.  According to a USA today arcle,  deaths from heat related injuries for athletes has more than doubled since 1975. The combinaon of hot weather and intense  exercise makes athletes vulnerable to injuries such as heat stroke and dehydraon. Some of the physiological condions in queson are rapid heart rate, high body temperature, and dehydraon. Our group is developing a sensor system that will measure  the heart rate, core body temperature, and electrolyc content of sweat to monitor signs of dehydraon and heat stroke. Heart  rate will be measured through electrodes connected to our designed electrocardiogram (ECG) circuit  that  will  feed  the  signal  into  a  microcontroller.  The signal will be exported to Matlab soware where heart rate calculaons will take place.  Core body temperature will be measured through  replicaon of ground‐breaking research conducted in Japan which created an external circuit capable of measuring and calculang core body temperature using the zero‐heat‐flow method. Electrolyc content of sweat is being determined by  measuring sweat conducvity – its ability to carry  current – by placing a small sample of sweat over  an array of four electrodes which will apply a constant current as well as measure the voltage drop  across the sample. The successful design and funconing of each of these components will prove to  be a monumental step toward our ulmate goal  of incorporang these sensors in a wearable device that will allow medical staff and athletes to take appropriate acon and prevent serious heat related injuries.

Athlete sensor

The physiological sensor consists of a conductivity sensor, ECG measurements and core body temperature sensor. The results from all three is sent to a microcontroller and then read on a laptop.

 

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