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For the Dr. Yawen Li category

Once again we say…Welcome Back

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Front row: Interim Director Dr.Elin Jensen, Faculty Yawen Li, 2ndRow Administrative support Bridgett Bailiff, Faculty Dr. Eric Meyer, Dr. Mansoor Nasir, and Dr. Jeff Morrissette

The biomedical engineering and life science faculty have been busy this past summer implementing new activities and opportunities for our freshman through senior students.  Returning students have noticed that room E108 – Bioinstrumentation Lab now has a new look.  The biomechanics gait analysis laboratory has secured funding from the DENSO Foundation to support research in human and machine interaction (see story on page xx).  We are very excited about this collaboration with the electrical engineering and robotic engineering programs.  Freshman students are enjoying working in the new collaboration space in room E109.   When you are on your way to the Environmental Scanning Electron Microscope or the BioMEMS laboratories, stop by to check out the new learning environment.

The Life Science Advisory Board welcomes two new members.  Mrs. Janelle Schrot from Materilize (MIMICS suite) and Dr. Ren You from Terumo Heart Inc. We look forward to working with these members and organizations as we continue to improve and expand the biomedical engineering program.

Finally, the biomedical engineering program thanks all the students and alumni who accepted the invitation to participate in the focus group meetings in the spring semester.  The focus groups provided valuable input on the needs and expectations of program graduates.  The biomedical engineering program educational objectives articulate the expected capabilities of graduates 3 to 5 years after graduation and they are:

  1. Graduates of the BSBME program apply foundational sciences and a wide range of engineering principles in order to lead cross-functional teams developing, designing, and verifying the function of medical technologies and services.   
  2.  Graduates of the BSBME program conduct translational biomedical engineering research while adhering to government compliance requirements and regulatory protocols.
  3.  Graduates of the BSBME program exhibit and demand the highest ethical and safety standards in their research and profession.
  4.  Graduates of the BSBME program are contributing members of the profession and society, and stay informed of current research and professional developments through advanced graduate studies and life-long education.

Enjoy your fall semester and your journey in discovering Lawrence Technological University!

BME Newsletter April 2013

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Modification of electrospun poly‐Ɛ‐caprolactone fibers for enhanced cell adhesion and proliferation – Spring 2013 Newsletter 

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Team Members: Manan Patel, Emily Boggs, Ahmad Arabi

Faculty Advisor : Dr. Yawen Li

Polycaprolactone (PCL) is gaining popularity in the field of tissue engineering due to its non‐toxic degradation byproducts and low-cost manufacturing method. It is also a markedly hydrophobic material, leading to subotopmal cell‐material interactions. Our study  aims to chemically modify electrospun PCL fibers to promote cell attachment, proliferation and extra cellular matrix (ECM) formation. This research project examines a two‐step modificaon technique to chemically and physically modify the surface of PCL  to increase cell‐material interacon and surface roughness respecvely. The first step ulizes sodium hydroxide (NaOH) to increase surface roughness with improved cell‐material interacons. Our preliminary results have shown decreased contact angle  and increased surface roughness with NaOH‐treated PCL fibers.  Second step is to immobilize a common pepde sequence that is  present in ECM of fibroblast cell by covalently aaching it to the PCL surface. Changes in the PCL fiber surface topography, hydrophilicity and chemistry will be evaluated using atomic force microscopy (AFM), contact angle measurement, x‐ray photoelectron  spectroscopy (XPS) and infrared spectroscopy (IR) respecvely. Human periodontal ligament fibroblast (HPDLF) cells will be seeded on the PCL fibers and their growth and proliferaon will be characterized using confocal microscopy, DAPI staining, AlamarBlue® assay and live/dead viability assay. We ancipate increased fibroblast adhesion, proliferaon and matrix formaon on the  treated PCL fibers. The results will have important implications for the use of PCL fibers as scaffold materials in regenerating a variety of tissues.

Braided PCL

Braided PCL scaffold imaged under environmental scanning electron microscope

Novel Design of a Three‐Dimensional Biomimetic Nanofiber Scaffold: Applications in Ligament Tissue Engineering – Spring 2013 Newsletter

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Team Members: John Schoenbeck, Christopher Lach, Reem Daher‐Nahhas

Faculty Advisor : Dr. Yawen Li

A commonly injured ligament in young adults that leads to degenerative diseases such as osteoarthritis is the Anterior Cruciate  Ligament (ACL) of the knee. Tissue Engineering has taken numerous steps in the past decade towards developing in‐vitro grown  ssue gras for the replacement of diseased and damaged ligaments. Previous research has shown that three‐dimensionally  paerned electrospun poly(ε‐caprolactone, PCL) nanofibers hold vast potenal as a biodegradable scaffold material for ligament  ssue engineering. The purpose of this research is to establish and characterize a novel braided scaffold design for use in ligament ssue engineering applicaons. In this study, a second-order triple helix braid concept was designed to mimic the hierarchal structure of collagen found in nave ACL tissues. Structural properties were analyzed using environmental scanning electron microscopy (ESEM) and porosimetry. Mechanical properes were characterized via tensile failure tesng. Cell compatibility was  determined by analyzing statically cultured cell‐seeded scaffolds via Live/Dead and AlamarBlue assays. Data analysis yields several promising outcomes: The structure of the braided scaffold closely mimics the structure of nave collagen and contains pores  that provide an ideal environment for cell growth. The mechanical properes of the braid match the ACL properes from literature and exceed those of previously aempted 3D fiber designs. Braid samples also prove to be compable with ligament fibroblasts in short‐term culture. The experimental protocols developed for this research will enable future studies to rapidly develop  new fiber braiding paerns and characterize their viability as ssue engineering scaffolds.

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